{"id":154,"date":"2026-07-27T22:32:49","date_gmt":"2026-07-27T22:32:49","guid":{"rendered":"https:\/\/www.dmmedicine.com\/nattokinaz-nedir-ne-ise-yarar\/"},"modified":"2026-07-27T22:32:49","modified_gmt":"2026-07-27T22:32:49","slug":"what-is-nattokinase-and-what-does-it-do","status":"publish","type":"post","link":"https:\/\/www.dmmedicine.com\/en\/nattokinaz-nedir-ne-ise-yarar\/","title":{"rendered":"What is Nattokinase and What Does It Do?"},"content":{"rendered":"<style>\n.dmblog{max-width:900px;margin:auto;color:#243b53;font-size:1.05rem;line-height:1.78}\n.dmblog h2{color:#087e8b;font-size:1.6rem;line-height:1.2;margin-top:1.8em}\n.dmblog h3{color:#102a43;margin:.2em 0}\n.dmblog .tag{color:#087e8b;font-weight:800;letter-spacing:.06em;text-transform:uppercase;font-size:.85rem}\n.dmblog .by{color:#627d98;font-size:.95rem;margin:.2em 0 1.4em}\n.dmblog .intro{font-size:1.08em;background:#fbf8f0;border-left:6px solid #e9823a;padding:20px 24px;border-radius:14px}\n.dmblog .intro p:last-child{margin-bottom:0}\n.dmblog .toc{background:#ddf4ef;padding:18px 22px;border-radius:14px;margin:22px 0}\n.dmblog .toc strong{display:block;color:#102a43;margin-bottom:6px}\n.dmblog .toc a{display:block;padding:3px 0;color:#087e8b;text-decoration:none}\n.dmblog .faq{padding:14px 0;border-top:1px solid #d9e2ec}\n.dmblog .note{background:#fff4e8;border:1px solid #f0c59e;padding:18px 22px;border-radius:14px;margin-top:30px}\n.dmblog .related{background:#f5f7f6;border-radius:14px;padding:18px 22px;margin-top:28px}\n.dmblog .related strong{display:block;color:#102a43;margin-bottom:8px}\n.dmblog .related a{color:#087e8b}\n.dmblog .cta{display:inline-block;margin-top:8px;background:#087e8b;color:#fff;padding:9px 18px;border-radius:10px;text-decoration:none;font-weight:700}\n.dmblog .sources{font-size:.9em;overflow-wrap:anywhere}\n<\/style>\n<div class=\"dmblog\">\n<p class=\"by\">DM MEDICINE CONTENT TEAM \u2022 Last updated: July 27, 2026<\/p>\n<div class=\"intro\">\n<p>Nattokinase is an enzyme derived from natto, a fermented soy product in Japanese cuisine. In recent years, it is frequently encountered in circulation support, vascular health, and healthy aging products.<\/p>\n<p>Although its name has only recently become well-known, natto is a food that has been consumed in Japan for centuries. Nattokinase, used as a supplement, is prepared to provide a specific enzymatic activity and offers a more concentrated form compared to the food.<\/p>\n<\/div>\n<nav class=\"toc\"><strong>What will we talk about in this article?<\/strong><a href=\"#nattokinaz-v\u00fccutta-ne-yapar\">1. What does nattokinase do in the body?<\/a><a href=\"#kimler-neden-tercih-ediyor\">2. Who chooses it and why?<\/a><a href=\"#fu-de\u011feri-ne-demek\">3. What does the FU value mean?<\/a><a href=\"#nas\u0131l-kullan\u0131l\u0131r\">4. How to use?<\/a><a href=\"#kimler-kullanmamal\u0131\">5. Who should not use it?<\/a><\/nav>\n<section>\n<h2 id=\"nattokinaz-v\u00fccutta-ne-yapar\">What does nattokinase do in the body?<\/h2>\n<p>Our body forms clots when necessary and then breaks down this structure in a controlled manner. Nattokinase is researched through processes related to fibrin, which forms the network structure of clots. For this reason, products are mostly presented under the headings of \u201ccirculation\u201d and \u201cvascular support.\u201d.<\/p>\n<p>There is an important distinction here: supporting circulation does not mean treating a heart attack or stroke. Nattokinase is not a natural alternative to the blood thinner prescribed by a doctor.<\/p>\n<\/section>\n<section>\n<h2 id=\"kimler-neden-tercih-ediyor\">Who chooses it, and why?<\/h2>\n<p>People who spend long hours at a desk, those with sedentary lifestyles, and those following a healthy aging program may be interested in this product. Some people choose it because of research on its effects on blood pressure and vascular elasticity.<\/p>\n<p>However, the best circulatory support remains movement, weight control, a smoke-free life, and regular blood pressure monitoring. Nattokinase should be considered as a special support added alongside these foundational steps.<\/p>\n<\/section>\n<section>\n<h2 id=\"fu-de\u011feri-ne-demek\">What does the FU value mean?<\/h2>\n<p>On nattokinase labels, we often see FU instead of milligrams. FU refers to fibrinolytic enzyme activity. Products providing 2,000 FU per serving are common on the market.<\/p>\n<p>It is not correct to look only at the total weight of the capsule. Actual enzyme activity depends on the product\u2019s manufacturing and storage quality. For this reason, the FU value and independent quality analysis are important.<\/p>\n<\/section>\n<section>\n<h2 id=\"nas\u0131l-kullan\u0131l\u0131r\">How do I use it?<\/h2>\n<p>The products are generally recommended to be taken as one capsule per day, separate from meals. The reason for this is to ensure that the enzyme is used for targeted circulatory processes rather than for breaking down dietary proteins. However, you should always follow the instructions on the product label.<\/p>\n<p>When using nattokinase for the first time, changes such as easy bruising, nosebleeds, or gum bleeding should be monitored. If a planned tooth extraction or surgery is scheduled, it must be reported to the healthcare team.<\/p>\n<\/section>\n<section>\n<h2 id=\"kimler-kullanmamal\u0131\">Who should not use it?<\/h2>\n<p>People taking medications that affect the risk of bleeding\u2014such as warfarin, apixaban, rivaroxaban, dabigatran, clopidogrel, or aspirin\u2014should not add nattokinase on their own. It may not be appropriate for those with bleeding disorders, a history of stroke, or active ulcers.<\/p>\n<p>There is insufficient data regarding use during pregnancy and breastfeeding. Conditions such as sudden, severe headache, black stools, or unexpected bleeding should not be dismissed as side effects of the supplement but should be evaluated immediately.<\/p>\n<\/section>\n<section>\n<h2>Frequently Asked Questions<\/h2>\n<div class=\"faq\">\n<h3>Is nattokinase a blood thinner?<\/h3>\n<p>It may affect circulation and fibrin processes; it is not a substitute for prescription blood thinners.<\/p>\n<\/div>\n<div class=\"faq\">\n<h3>Is eating natto the same thing?<\/h3>\n<p>Natto is a food; the supplement is standardized to provide a specific level of enzymatic activity.<\/p>\n<\/div>\n<div class=\"faq\">\n<h3>On an empty or full stomach?<\/h3>\n<p>Many products recommend taking them between meals; follow the instructions on the label.<\/p>\n<\/div>\n<\/section>\n<aside class=\"toc\"><strong>Would you like to select the appropriate support for you?<\/strong> You can review the options that suit your needs in the DM Medicine product selection by comparing the amount of ingredients, form, and purpose of use. <a class=\"cta\" href=\"\/en\/store\/\">Check out the store \u2192<\/a><\/aside>\n<aside class=\"note\"><strong>A small but important note:<\/strong> This article has been prepared for general informational purposes. Dietary supplements do not replace a normal diet. If you use regular medication, have a chronic illness, are pregnant or breastfeeding, or plan to have surgery, consult your doctor or pharmacist before use.<\/aside>\n<section class=\"sources\">\n<h2>Sources and Further Reading<\/h2>\n<ol>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=nattokinase+clinical+trial\" target=\"_blank\" rel=\"noopener noreferrer\">Source 1<\/a><\/li>\n<li><a href=\"https:\/\/www.nccih.nih.gov\/health\/using-dietary-supplements-wisely\" target=\"_blank\" rel=\"noopener noreferrer\">Source 2<\/a><\/li>\n<\/ol>\n<\/section>\n<div class=\"related\"><strong>Related articles<\/strong><\/p>\n<ul>\n<li><a href=\"\/en\/what-is-berberine-and-how-to-use-it-daily\/\">What is Berberine? How many mg should be taken daily?<\/a><\/li>\n<li><a href=\"\/en\/what-is-nad-and-nmn\/\">What Are NAD+ and NMN? How Do They Support Healthy Aging?<\/a><\/li>\n<li><a href=\"\/en\/what-is-urolithin-a\/\">What is Urolithin A? How Does It Support Energy and Muscle Health?<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>What is nattokinase, how is it used? Circulation, fibrin, blood pressure, FU value, timing of use, and use with blood thinners.<\/p>","protected":false},"author":1,"featured_media":131,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40],"tags":[],"class_list":["post-154","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rehber"],"_links":{"self":[{"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/posts\/154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/comments?post=154"}],"version-history":[{"count":0,"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/posts\/154\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/media\/131"}],"wp:attachment":[{"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/media?parent=154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/categories?post=154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.dmmedicine.com\/en\/wp-json\/wp\/v2\/tags?post=154"}],"curies":[{"name":"well played","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}